Tissue preservation & Bio-banking

Biography

Biography: Vimal Karani S

Abstract

The concept of "Personalized" Medicine is now being extended to the field of Nutrigenetics, which investigates the impact of gene variation responses to intake of different nutrients. The ability of Nutrigenetics to determine what nutrients will produce the desired impact on metabolic balance (as influenced by individual genetic make-up) is at the core of Personalized Nutrition. Obesity is a heritable trait that arises from the interactions between multiple genes and lifestyle factors such as diet and physical inactivity. Dietary factors play an important role in the development of obesity because of the variation in the food that is being consumed in different parts of the world. Although several studies have examined the gene x nutrient interactions, the findings have been quite inconsistent and hence, unable to develop an optimum diet for each ancestral population. Some of the challenges in performing nutrigenetics research are 1) genetic heterogeneity, 2) lack of understanding of the metabolic pathways and 3) insufficient sample size. With genome-wide association study (GWAS) data now available on numerous large cohorts, it has become possible to embed candidate gene studies within GWASs, testing for association on a much larger number of candidate genes than previously possible. The talk will highlight three main aspects: 1). Why do we do gene-diet interaction analysis? – Findings from DiOGenes study, 2). Why large samples are required to conduct genetic epidemiological studies? – Findings from D-CarDia Collaboration and 3). Nutrigenetics in developing countries – Findings from GeNuIne Collaboration