Henry Li
Crown Bioscience, Inc, USA
Title: Fully annotated PDX library as a live and renewable biobank to support biomarker discovery and guide precision treatment
Biography
Biography: Henry Li
Abstract
Cancers are diverse diseases, with various histo-/molecular pathogenesis, and respond vastly different to treatments. Optimal therapy needs to be precise and personalized, which demands accurate diagnosis and modeling. We recently developed a new molecular diagnostic tool, HuDiagnosisTM, that can precisely diagnose cancer diseases using NGS per a novel molecular pathology algorithm, to guide precision therapy. This tool, with equivalency to classic histopathology but significantly more reliable and objective, can also be particularly useful in annotating biobank. In addition, we have also built the largest patient derived xenograft (PDX) library of >3,000 models covering divers cancer types with full annotation of histo-/molecular pathology, growth and treatment information. This growing library, with intent as experimental model to support population-based investigations (clinic styled) at preclinical setting (mouse clinical trial -- MCT), is also a live and renewable biobank that can be used to facilitate various biobank functions, e.g. biomarker discovery. In particular, together with experimental efficacy readout, this live bank can greatly enhance predictive biomarker exploration.